![]() Hubbell’s laboratoriesĬonjugation Efficiency and Yield Hexaglycine input Conjugation efficiency Hexaglycine input Conjugation yield Targeted yield * * Based on work with PEG hydrogels in J. (submitted) J Biomed Mater Res * Peptides of interest: Cell adhesive fibronectin peptide (GRGDSG) Model peptide, hexaglycine (GGGGGG) * Based on work with PEG hydrogels in J. ![]() Peptide-Conjugated GMHA Hydrogels Baier Leach J, Bivens KA, Collins CN, & Schmidt CE. In Vivo Analysis of EC Infiltration Fibrin (+) GMHA hydrogel 6.63 ± 1.10, n = 9 (% area CD31-positive cells)7.06 ± 0.14, n = 4 2 Week Implant Scale, 200 mm Agarose (-) EC immunostain (CD31) In Vivo Analysis of Endothelial Cell (EC) Infiltration Fill TEC with hydrogel 4 hydrogels per rat + Control: Fibrin -Control: Agarose 2 HA gels 2. Harvest tissue at 2 weeks (side view without TEC) 1. Media Hydrogel Crosslinked GMHA 1% GMHA 0.1% Irgacure 2959 0.03% N-vinyl pyrrolidinone 1 minute UV Crosslinked GMHA GMHA in solution Media HA n>6 for each bar Effect of Methacrylation on Cytocompatibility HAEC monolayer
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